Deflagyn

DeflaGyn is available as a vaginal gel, packaged in bottles with 2 reusable applicators. This allows optimal and direct administration of the gel to the cervix. 

The gel, used in combination with the applicator, ensures correct and effective dosing, making it easy for patients to use.

DeflaGyn is indicated in cases of:

• Unclear cervical smears: ASC-US, LSIL, ASC-H, HSIL, PAP II-p, PAP III-p, PAP IIID1, PAP IIID2, PAP III and PAP IIID.
• HPV-induced cervical lesions
• Cervical lesions p16/Ki-67 positive
• Cervical erosions: can help heal and prevent their progression.

The gel helps relieve symptoms and reduces the risk of lesion progression, promoting spontaneous remission. According to gynecological guidelines, DeflaGyn is commonly used as an adjuvant in the "watchful waiting" period, where regular assessments and non-invasive treatments are preferred.

The recommended dose is 5 ml of gel, applied daily for 3 treatment cycles of 28 days each.

1. For patients without menstruation: DeflaGyn is administered once daily for 28 days, followed by a 3-day break. Repeat the same cycle for two more 28-day courses, with breaks between each course.
2. For menstruating patients: the treatment is applied outside the menstrual period, and the additional 3-day break is not necessary, as menstruation itself is considered a break.

DeflaGyn HPV is contraindicated in the following situations:

• Allergies to any of its ingredients, especially silicon dioxide, citric acid or sodium selenite
• Pregnant or breastfeeding women should consult their doctor before use, as there are insufficient data on safety in these periods

To correctly administer the gel dose, users must use the included applicator. Shake the bottle, extract 5 ml of gel and insert it deep into the vagina up to the cervix.

It is important to clean the applicator before each use. It should not be used if it shows signs of damage.

After application, the gel may appear slightly reddish when washed off, with the potential to discolor underwear.

DeflaGyn is generally well tolerated, but mild side effects may occur, such as:

• Burning, discomfort or itching on application
• Allergic reactions: in rare cases, allergic reactions to silicon dioxide or other ingredients of the product may occur

If unusual symptoms persist, use should be discontinued and a doctor should be consulted.

DeflaGyn is a topical medical device and the risk of drug interactions is low. 

However, concomitant use with other vaginal products is not recommended as it may reduce the effectiveness of the treatment.

Therefore, additional intravaginal topical treatments such as ovules or other vaginal gels should be applied at least 2 hours before or after using DeflaGyn. Preferably, you can give one treatment in the morning and one in the evening.

Overdose with DeflaGyn is unlikely due to the way it is taken. However, excessive use may cause vaginal irritation and discomfort. 

It is advisable to follow the dosage indicated to avoid unpleasant manifestations.

DeflaGyn should be stored in a dry place at temperatures below 25°C, away from direct light and moisture. It should not be left out of the reach of children and should be used before the expiry date indicated on the packaging.

• BMJ Journals, 2022-RA-421-ESGO DeflaGyn® has cytotoxic, genotoxic and apoptotic effects on human adenocarcinoma cells
• Springer, Efficacy and safety of a vaginal adsorbent and antioxidant gel on CIN1 and 2, high-risk HPV and p16/Ki-67
• Pubmed, Successful preventive treatment of oncogenic transforming HPV infections in patients with low-grade cytology (ASC-US/LSIL) with an adsorbent and antioxidant vaginal gel
• Healthline, What are neck injuries and what do they mean?